The  arteries feeding the penis expand and the smooth muscle relaxes, opening up tiny  sacs in the erectile tissue that then swell with blood.    The  two main chambers of the penis, the corpus cavernosum, fill and the organ becomes so engorged that the veins that usually drain away blood are pressed shut  against the tough outer membrane of the erectile chambers. The result is  erection.  Flavonoid and Flavonoid glycoside from Butea Superba Roxb and their cASVIP Phosphodieterase Inhibitory Activity.

Flavonoid and Flavonoid Glycoside from Butea Superba Roxb and their cASVIP Phosphodiesterase Inhibitory Activity

Abstract

Flavonoid(3,7,3'-trihydroy-4'-methoxyflavaone)(1) and flavonoid glycosides dihydoxy-4'-methuxyflavone-7-0-p.-D-glucopyranoside)  (2) were isolated from the roots of Butea Superba Roxb.  The structures were determined on the basis of spectral analysis 2d-nmr lechiik-lues.  These compounds show strong inhibitory effects on cAMD phospodiesterase.

Introduction

Butea Superba Roxb. is a herb in the Family  Papilionaceae and has the characteristics of a crawer that wraps itself around large trees.  One branch has 3 leaves, the flowers are a yellowish color and the plant grow's out in the open.  The long roots of the plant are buried under the "the round like roots of the yam."  This type of plant reproduces through seeds and the separation of its roots.  This plant can be found growing in forests in the northern regions, in the eastern regions and along Karnchanaburi Province.  The roots  and stem of the plant are used for medicines for strength and power.  In addition, the roots and stem of the plant are considered to help increase male sexual performance. Thus, this plant has come to be known as one type of miracle herb.  The bioactivity of each constituent was tested, especially the cAMP phophodiesterase inhibitory effects in controlling a number of diseases(1).  Therefore, the research conducted was designed to test the hypothesis that the chemical constituents of this plant is actually capable in enhancing certain physiological functions.

Results

 From testing the bioactivity of Flavonoid and Flavonoid glycoside, it was found that both of these compounds were effective in inhibiting cAMP phosphodieterase. The result of inhibiting cAMP phosphodiesterase of both these compounds was greater than theophylline (IC50 =615 u.g/mL) and caffeine (IC50 = 420 u.g/rnL). The cAMP phosphodiesterase enzyme has a main function in the hydrolysis of the intracellular cAMP.  Some compounds  that inhibit cAMP phosphodiesterase are therefore capable of stimulating the functioning of the central nervous system (CNS) and stimulating the functioning of cells.